反应详情

A solution of 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (Example 14e) (254 mg) in acetonitrile (5 mL) was treated with 2 -chloro-N-pyridin-2-yl-acetamide (Example 140 (146 mg) and the resulting yellow solution was stirred at room temperature overnight during which time a solid precipitated. The reaction mixture was treated with ˜2 mL of ether and the solid was filtered off, washed with ether and dried under vacuum to give the title compound as an off-white solid (217 mg). Crystallisation from refluxing acetonitrile (20 mL) gave 98 mg of the titled compound as a white crystalline solid.

1. customprecipitated
2. additionThe reaction mixture was treated with ˜2 mL of ether
3. filtrationthe solid was filtered off
4. washwashed with ether
5. customdried under vacuum