反应详情

1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (0.79 mmol) and 2-bromo-N-pyridin-2-yl-acetamide (Example 15a) (0.87 mmol) were stirred together in anhydrous MeCN at room temperature for 2.5 days. The reaction mixture was concentrated in vacuo and the yellow solid purified by flash silica gel column chromatography eluting with 2-8% MeOH/dichloromethane to give a tan solid which crystallised from boiling MeCN to give the titled compound as a white solid (211 mg).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe yellow solid purified by flash silica gel column chromatography
3. washeluting with 2-8% MeOH/dichloromethane
4. customto give a tan solid which
5. customcrystallised