Water → 2-Bromo-N-phenylacetamide

Participants

Reaction Steps

To a solution of bromoacetyl bromide (9.6 mL) and potassium carbonate (11.4 g) in dichloromethane (100 mL) was added aniline (5 mL) dropwise over 15-20 mins causing the reaction mixture to get warm and a white precipitate to form. After 4.5 h the reaction mixture was poured into water, shaken for several minutes and then the phases were separated. The organic layer was washed with water and concentrated to a smaller volume resulting in precipitation of a solid that was filtered off to give the sub-titled compound (970 mg) as a white solid.

Provenance & Evidence