HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 86655280, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-Bromo-N-phenylacetamide | HCID 94818 | — |
| Reactant | 1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester | HCID 59179619 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86655280 | HCID 86655280 | 47.2% |
Reaction Steps
To 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (50 mg) in acetonitrile (1 mL) was added 2-bromo-N-phenylacetamide (Example 21a) (36 mg). The reaction mixture was stirred at room temperature for 3 days. Ether was added to the reaction mixture and the resultant solid was collected by filtration and dried to afford the title compound as a colourless solid (39 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329729B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-274755c5888f41e59143360add27ba86 |
| Source note | uspto-grants-2012_12 |