1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester → HCID 53311102, compound

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Reaction Steps

1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (0.44 mmol) and 2-chloro-N-pyrimidin-4-yl-acetamide (Example 22a) (0.48 mmol) in anhydrous MeCN (2 mL) were stirred together at room temperature for 2.5 days. The reaction mixture was concentrated in vacuo and the residue purified by flash silica gel chromatography (2-10% MeOH/dichloromethane) to give the title compound as a light yellow solid (134 mg).

Provenance & Evidence