1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester → HCID 86655282, compound

Participants

Reaction Steps

2-Chloro-N-(5-fluoro-pyridin-3-yl)-acetamide (Example 28a) (53 mg) was added to a solution of 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (Example 14e) (84 mg) in acetonitrile (2 mL). The reaction mixture was allowed to stir at room temperature for 24 h. The solid was filtered off and dried under vacuum at 40° C. to give the title compound (47 mg, 35%) as a white solid.

Provenance & Evidence