関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Carbon tetrabromide | HCID 11205 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 2-(Pyridin-3-yloxy)ethan-1-ol | HCID 21908997 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(2-Bromoethoxy)pyridine | HCID 10679598 | 70.2% |
反応手順
A solution of 2-(pyridin-3-yloxy)-ethanol (200 mg) in 5 mL dichloromethane was cooled to 0° C. and treated with carbon tetrabromide (524 mg) followed by triphenylphosphine (415 mg) portionwise. The reaction mixture was stirred at 0° C. for 30 mins then at room temperature for 45 mins. The volatiles were evaporated and the residue purified by silica gel chromatography eluting with 0-100% EtOAc/pentane to give the title compound (204 mg) as a colourless liquid which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08329729B2 |
|---|
| 出典データセット | uspto-grants-2012_12 |
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| ORD ID | ord-16c25788f19d41d7b4f90dc81d9742d4 |
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| 出典メモ | uspto-grants-2012_12 |
|---|
