反应详情

2-(2-Bromo-ethyl)-pyrazine (Example 32a) (43 mg) was added to a solution of 1-phenyl -cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (50 mg) in acetonitrile (1 mL). The reaction mixture was allowed to stir at room temperature for 68 h. The volatiles were evaporated and the product was purified by silica gel chromatography eluting with 0-20% MeOH/dichloromethane. The relevant fractions were combined and concentrated, dissolved up in dichloromethane, filtered and evaporated to give the title compound (30 mg) as a yellow gummy glass.

1. customThe volatiles were evaporated
2. customthe product was purified by silica gel chromatography
3. washeluting with 0-20% MeOH/dichloromethane
4. concentrationconcentrated
5. dissolutiondissolved up in dichloromethane
6. filtrationfiltered
7. customevaporated