HCID 10879224, compound → HCID 53311259, compound

Participants

Reaction Steps

A mixture of 4-(3-bromo-propoxy)-benzonitrile (41 mg) and 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (52 mg) in MeCN (1 mL) was stirred at room temperature for 16 h then heated to 80° C. under nitrogen for a further 16 h. The volatiles were evaporated and the residue was triturated with ether to give an off-white solid that was triturated with EtOAc and dried under vacuum to give the title compound (61 mg) as a white solid.

Provenance & Evidence