1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester → HCID 86655287, compound

Participants

Reaction Steps

A mixture of 2-bromo-N-(2,5-difluoro-phenyl)-acetamide (Example 41a) (47 mg) and 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (56 mg) in MeCN (1 mL) was stirred at room temperature for 30 h. The resulting precipitate was filtered off, washed with ether and dried at 50° C. under vacuum overnight to afford the title compound (65 mg) as a colourless solid.

Provenance & Evidence