1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester → HCID 67027752, compound

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Reaction Steps

A mixture of 4-(2-bromo-ethoxymethyl)-benzonitrile (41 mg, 0.17 mmol) and 1-phenyl -cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (51 mg) in MeCN (1 mL) was stirred at room temperature for 16 h then heated to 80° C. under nitrogen overnight. The resulting solid was filtered off, washed with ether and dried under vacuum to give the title compound (70 mg) as a white solid.

Provenance & Evidence