HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-N-(4-methylpyridin-2-yl)acetamide → HCID 53311263, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-N-(4-methylpyridin-2-yl)acetamide | HCID 2776797 | — |
| Reactant | 1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester | HCID 59179619 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 53311263 | HCID 53311263 | 51.2% |
Reaction Steps
To a solution of 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3yl) ester (Example 14e) (100 mg) in 1 mL MeCN was added 2-chloro-N-(4-methyl-pyridin-2-yl)-acetamide (Example 44a) (62 mg) and the mixture was stirred at room temperature for 21 h. The precipitate was filtered off and dried under vacuum at 50° C. to give the title compound (80 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329729B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-cbc8ad22c72b41c6bd36c586b1d76aaa |
| Source note | uspto-grants-2012_12 |