2-bromo-N-(3-methylphenyl)acetamide → HCID 86655291, compound

Participants

Reaction Steps

To 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (50 mg) in acetonitrile (1 mL) was added 2-bromo-N-m-tolyl-acetamide (Example 47a) (38 mg). The reaction was stirred at room temperature for 26 hours and the acetonitrile was removed under reduced pressure. The material was purified by silica gel chromatography eluting with 0-10% MeOH/dichloromethane to afford the title compound (37 mg) as a colourless foam.

Provenance & Evidence