反应详情

1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (Example 14e) (0.30 mmol) and 2-chloro-N-(3-fluoro-pyridin-4-yl)-acetamide (Example 54a) ( mmol) in MeCN (1.5 mL) were stirred together at room temperature overnight. The reaction mixture was concentrated in vacuo and the residue purified by silica gel chromatography eluting with 0-10% MeH/dichloromethane to give the title compound a white solid (110 mg).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue purified by silica gel chromatography
3. washeluting with 0-10% MeH/dichloromethane