1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester → HCID 67310398, compound

Participants

Reaction Steps

Pyrazine-2-carboxylic acid (2-bromo-ethyl)-amide (Example 55a) (87 mg) was added to a solution of 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (Example 14e) (113 mg) in acetonitrile (2 mL). The reaction mixture was allowed to stir at room temperature for 16 h. A solid precipitated out and was filtered off, washed with cold acetonitrile and dried under vacuum at 40° C. to give the title compound (96 mg) as a white solid.

Provenance & Evidence