Ethyl Acetate → HCID 58149933, compound

Participants

Reaction Steps

The contents of the three vials were pooled with the reaction mixture from a previous preparation of D6 (using the same method and 100 mg of chloroquinoline starting material), and the mixture diluted with ethyl acetate and washed sequentially with brine (×2) and water (×2). The organic layers were concentrated in vacuo to give a red oil that was dissolved in dichloromethane, and purified by flash chromatography on silica gel, eluting with a dichloromethane/ethyl acetate (2% to 20% EtOAc) gradient. The relevant fractions were pooled and concentrated in vacuo to give a red solid that was triturated with diethyl ether. The resulting brick coloured solid was collected by filtration and dried in vacuo to give the title compound (80 mg, 8%).

Provenance & Evidence