HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Chloro-4-[(difluoromethyl)oxy]benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Chloro-4-(difluoromethoxy)benzoic acid | HCID 58149932 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Chloro-4-[(difluoromethyl)oxy]benzoyl chloride | HCID 58149922 | 125.3% |
Reaction Steps
3-Chloro-4-[(difluoromethyl)oxy]benzoic acid (D17; 0.28 g, 1.258 mmol) was stirred at room temperature with oxalyl chloride (0.220 mL, 2.52 mmol) and N,N-dimethylformamide (DMF) (0.05 ml) in dry dichloromethane (DCM) (5 ml) under nitrogen for 16 h. The solvent was evaporated in vacuo to give a yellow semi-solid (380 mg) which was used crude in the subsequent reaction D47.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329730B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-65426e63b3224c6a8ff4f11149b4bb70 |
| Source note | uspto-grants-2012_12 |