Hydrochloric Acid → HCID 66876379, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethylethyl N-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-β-alaninate (D9; 20 mg, 0.039 mmol) and 0.5M HCl in 1,4-dioxane (10 ml) were stirred at room temperature for 2.5 h. The reaction mixture was then heated to 50° C. for a further 30 minutes, cooled and evaporated to dryness. The resulting solid was triturated with ether and 1,4-dioxane to yield the title compound (20 mg) as a white solid.

Provenance & Evidence