Methanol → HCID 66877619, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-4-piperidinecarboxylate (D14; 35 mg, 0.067 mmol), tetrahydrofuran (THF) (2.0 ml), methanol (2.0 ml), water (1 ml) and lithium hydroxide (1.61 mg, 0.067 mmol) was left to stir at 80° C. for 3 h. The solvent was removed in vacuo and the residue was triturated with diethyl ether. The mixture was filtered to give the title compound as a pale peach coloured solid (20 mg).

Provenance & Evidence