Dichloromethane → HCID 66876691, compound

Participants

Reaction Steps

1,1-Dimethylethyl 4-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-1-piperazinecarboxylate (D15; 24 mg, 0.044 mmol), trifluoroacetic acid (1 ml, 13.0 mmol) and dichloromethane (1 ml) were stirred at room temperature for 1 h. The samples were dissolved in DMSO (1 ml) and purified by Mass Directed Preparative HPLC (supelcosil ABZ+Plus alkylamide phase column), eluting with solvents A/B (A: water+0.1% formic acid, B: MeCN:Water 95:5+0.05% formic acid). The solvent was evaporated in vacuo to give the title compound as a white solid (16 mg).

Provenance & Evidence