HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 44476316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-Chloro-4-(propan-2-yloxy)benzoic acid | HCID 22597728 | — |
| Reactant | HCID 178513273 | HCID 178513273 | — |
| Product | HCID 44476316 | HCID 44476316 | 37.8% |
Reaction Steps
A microwave vial was charged with HATU (2.5 g, 6.57 mmol), triethylamine (1.48 ml, 10.7 mmol), 3-chloro-4-[(1-methylethyl)oxy]benzoic acid (D3; 1.15 g, 5.34 mmol) and N-hydroxy-5-isoquinolinecarboximidamide (D1; 1 g, 5.34 mmol). The solution was stirred at room temperature for 30 minutes. The reaction vessel was sealed and heated under microwave irradiation at 130° C. for 120 min. After cooling, the reaction mixture was filtered. The isolated grey-brown solid was washed with acetonitrile before being dried in vacuo at 60° C. to give the title compound as a grey solid (738 mg, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329730B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-70fa40092edf4600afcd5c8de4f6e18a |
| Source note | uspto-grants-2012_12 |