HCID 58149882, compound → HCID 44476675, compound

Participants

Reaction Steps

1,1-Dimethylethyl 3-[5-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate (D53; 54 mg, 0.111 mmol) was dissolved in 4M hydrogen chloride in 1,4-dioxane (10 ml) and the mixture allowed to stand at room temperature for 2 h. The solvent was evaporated in vacuo to give a colourless gum which was triturated under dry ether (5 ml) to give a white solid which was dissolved in NMP (0.5 ml) and purified by Mass Directed Preparative HPLC (Supelcosil ABZ+Plus column, eluting with solvents A/B (A: Water+0.1% Formic acid, B: MeCN:Water 95:5+0.05% Formic acid)). The solvent was evaporated in vacuo to give the title compound (2.2 mg)

Provenance & Evidence