1,1-Dimethylethyl 3-[5-(5-{3-cyano-4-[(2,2,2-trifluoroethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate → 3-[5-(5-{3-Cyano-4-[(2,2,2-trifluoroethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoic acid

Participants

Reaction Steps

1,1-Dimethylethyl 3-[5-(5-{3-cyano-4-[(2,2,2-trifluoroethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate (D49; 164 mg, 0.313 mmol) was stirred in 4M HCl in dioxane (3 ml) at room temperature for 2.5 hrs. The solvent was removed under vacuum and the residue was triturated under diethyl ether. Filtration provided a solid that was dried in a vacuum oven to give the title compound as a white solid (125 mg).

Provenance & Evidence