HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2192608Generated: October 26, 2026
Hydrochloric Acid → 3-Amino-6-(2,6-difluorophenyl)picolinic acid
https://huagongshe.com/reaction/2192608
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-amino-6-(2,6-difluorophenyl)picolinate | HCID 59226548 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Amino-6-(2,6-difluorophenyl)picolinic acid | HCID 59226428 | 90% |
Reaction Steps
To a solution of methyl 3-amino-6-(2,6-difluorophenyl)picolinate (1.0 equiv) in THF (0.5 M), was added 1M LiOH (4.0 equiv). After stirring for 4 hours at 60° C., 1 N HCl (4.0 equiv.) was added and the THF was removed in vacuo. The resulting solid was filtered and rinsed with cold H2O (3×20 mL) to yield 3-amino-6-(2,6-difluorophenyl)picolinic acid (90%). LCMS (m/z): 251.1 (MH+); LC Rt=2.1 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08329732B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-c6e0986781ac4cf09b00f0d549eb9430 |
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| Source note | uspto-grants-2012_12 |
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