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HRID2192610

反应详情

EQUATION

反应方程式

HRID 2192610 的结构方程式

REACTANTS

反应物

2
结构：CCCOc1ccc(F)c(B(O)O)c1
HCID16217464

(2-Fluoro-5-propoxyphenyl)boronic acid

C9H12BFO3

结构：Nc1cc(F)c(Br)nc1C(=O)O
HCID72698879

3-Amino-6-bromo-5-fluoro-2-pyridinecarboxylic acid

C6H4BrFN2O2

PRODUCTS

生成物

1
结构：CCCOc1ccc(F)c(-c2nc(C(=O)O)c(N)cc2F)c1
HCID59226511

未命名化合物

收率 28%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1
催化剂HCID178418807

未命名化合物

PROCEDURE

实验过程

Method 1 was followed using 3-amino-6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-propoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 3-amino-5-fluoro-6-(2-fluoro-5-propoxyphenyl)picolinic acid in 28% yield. LC/MS=309.1 (M+H), Rt=1.00 min.