HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromopyridine-2-carboxylic acid → HCID 53223070, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromopyridine-2-carboxylic acid | HCID 593919 | — |
| Reactant | 2,6-Difluorophenylboronic acid | HCID 2734336 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | HCID 53223070 | HCID 53223070 | 38% |
Reaction Steps
Method 1 was followed using 6-bromopicolinic acid (1.0 equiv.) and 2,6-difluorophenylboronic acid (1.5 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 6-(2,6-difluorophenyl)picolinic acid in 38% yield. LC/MS=236.0 (M+H), Rt=0.87 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329732B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ab7a764d514b43d88c0f2283f686be9d |
| Source note | uspto-grants-2012_12 |