HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromopyridine-2-carboxylic acid → 6-(2-Fluoro-5-propoxyphenyl)picolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromopyridine-2-carboxylic acid | HCID 593919 | — |
| Reactant | (2-Fluoro-5-propoxyphenyl)boronic acid | HCID 16217464 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 6-(2-Fluoro-5-propoxyphenyl)picolinic acid | HCID 59226589 | 20% |
Reaction Steps
Method 1 was followed using 6-bromopicolinic acid (1.0 equiv.) and 2-fluoro-5-propoxyphenylboronic acid (1.5 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 6-(2-fluoro-5-propoxyphenyl)picolinic acid in 20% yield. LC/MS=276.0 (M+H), Rt=0.87 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329732B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e1db03b8592d41aab5c22813dcba77f4 |
| Source note | uspto-grants-2012_12 |