HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Fluoro-5-methoxyphenylboronic acid → 5-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Fluoro-5-methoxyphenylboronic acid | HCID 4157211 | — |
| Edukt | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Produkt | 5-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid | HCID 59226605 | 86% |
Reaktionsschritte
Method 1 was followed using 6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-methoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 5-fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid in 86% yield. LC/MS=266.1 (M+H), Rt=0.79 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08329732B2 |
| Quelldatensatz | uspto-grants-2012_12 |
| ORD ID | ord-35ccb7822f1b4403a0042376ce039609 |
| Quellennotiz | uspto-grants-2012_12 |