HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-ene → HCID 59226540, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-ene | HCID 3697076 | — |
| Reactant | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | HCID 59226540 | HCID 59226540 | — |
Reaction Steps
Method 1 was followed using 6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane (2.0 equiv.) and Pd(dppf)Cl2-DCM (0.2 equiv.) to give 5-fluoro-6-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)picolinic acid. LC/MS=280.2 (M+H), Rt=0.66 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329732B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ff58443abe4d42f8b3f82669cafb6c6f |
| Source note | uspto-grants-2012_12 |