HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoro-3-methoxybenzeneboronic acid → 2-(2,6-Difluoro-3-methoxyphenyl)-3-fluoro-6-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoro-3-methoxybenzeneboronic acid | HCID 2783131 | — |
| Reactant | 2-Bromo-3-fluoro-6-methylpyridine | HCID 24820318 | — |
| Product | 2-(2,6-Difluoro-3-methoxyphenyl)-3-fluoro-6-methylpyridine | HCID 59226406 | 60% |
Reaction Steps
Method 4 was followed using 2-bromo-3-fluoro-6-methylpyridine (1.0 equiv.) and 2,6-difluoro-3-methoxyphenylboronic acid (2.0 equiv.) to give 2-(2,6-difluoro-3-methoxyphenyl)-3-fluoro-6-methylpyridine in 60% yield. LC/MS=254.1 (M+H), Rt=0.85 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329732B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-743921092823404889343a8904296a33 |
| Source note | uspto-grants-2012_12 |