HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-5-fluoropicolinic Acid → HCID 86639737, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| Reactant | HCID 68548666 | HCID 68548666 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86639737 | HCID 86639737 | — |
Reaction Steps
Following Method 9, 4-((1R,3R,4S,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-methylcyclohexyl)pyridin-3-amine and 6-bromo-5-fluoropicolinic acid were coupled and following addition of EtOAc and washing with H2O, NaCl(sat.) and drying over MgSO4, N-(4-((1R,3R,4S,5R)-3,4-bis(tert-butyldimethylsilyloxy)-5-methylcyclohexyl)pyridin-3-yl)-6-bromo-5-fluoropicolinamide was obtained. LCMS (m/z): 652.5, 652.4 (MH+); LC Rt=5.82 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329732B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-29b25c13558f40b58c6de87536c41e01 |
| Source note | uspto-grants-2012_12 |