Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Hydroxy-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-carboxamide | HCID 13271630 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25029987 | HCID 25029987 | — |
Reaction Steps
3.93 g (15 mmol) of the derivative 3-(4-nitrobenzyl)-5-hydroxy-3H-imidazole-4-carboxamide are added to 80 ml of DMF in a three-necked flask under argon, followed by addition of 8.29 g (60 mmol; 4 eq.) of potassium carbonate. The stirred medium is maintained at 50° C. for 30 minutes and then cooled to room temperature. Methyl iodide (5.75 g; 40.5 mmol; 2.7 eq.) is then added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08329738B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-adfa943e936a4b138513a4c0cef2d949 |
|---|
| Source note | uspto-grants-2012_12 |
|---|
