Methyl iodide → HCID 25030229, compound

Participants

Reaction Steps

200 mg (0.517 mmol) of 5-hydroxy-3-{4-[(naphthalene-1-carbonyl)amino]benzyl}-3H-imidazole-4-carboxamide are dissolved in 5 ml of dry DMF in a round-bottomed flask under argon. 285 mg (2.07 mmol; 4 eq.) of potassium carbonate are then added. After one hour at room temperature, 440 mg (3.1 mmol; 6 eq.) of methyl iodide are added. After stirring for 24 hours at room temperature, the reaction medium is poured into brine and a precipitate appears. After stirring for 20 minutes, the precipitate is filtered off and then washed with water. After drying, 72 mg of a white solid are obtained.

Provenance & Evidence