Hydrogen chloride-ethyl acetate → HCID 68432330, compound

HRID 2192786Notes

Reaction equation

HRID 2192786 reaction equation
[NH2:1][C:2]([C@@H:4]1[CH2:9][C@H:8]([N:10]([C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)=[O:3].C(OCC)(=O)C.[ClH:47]>>[ClH:47].[ClH:47].[NH2:1][C:2]([C@@H:4]1[CH2:5][NH:6][CH2:7][C@H:8]([N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:9]1)=[O:3]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59625490tert-butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate

Product 1

HCID 68432330HCID 68432330, compound

Procedure

tert-Butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate (230 mg) was dissolved in 1 M hydrogen chloride-ethyl acetate (4 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, ethyl acetate was added and the precipitate was collected by filtration and washed with ethyl acetate to give the object compound (218 mg).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionethyl acetate was added
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-3ef6f23b6d3d44dabd872fffb81d7810
Source dataset
uspto-grants-2012_12
Patent number
US08329691B2

Reaction notes

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