Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 68433282 | HCID 68433282 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 59625400 | HCID 59625400 | 217.7% |
Reaction Steps
Sodium 2-oxocyclohexylidenemethanolate (15 g), 2-cyanoacetamide (4.3 g) and piperidine (1.0 ml) were suspended in water (35 ml), and the mixture was stirred at 40° C. for 4 days. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was suspended in methanol, and insoluble material was filtered off. The filtrate was concentrated under reduced pressure to give the object compound (21.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08329691B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-e136f660179446f39ba52a38e16bbb70 |
|---|
| Source note | uspto-grants-2012_12 |
|---|
