Triethylamine → HCID 59625518, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-[({2-tert-butyl-4-[(furan-2-ylmethyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-(hydroxymethyl)piperidine-1-carboxylate (420 mg) and triethylamine (0.87 ml) in DMSO (6 ml) was added dropwise a solution of sulfur trioxide pyridine complex (500 mg) in DMSO (5 ml) at room temperature, and the mixture was stirred at room temperature for 10 hr. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and the fraction eluted with ethyl acetate-hexane (5:95-70:30) was concentrated under reduced pressure to give the object compound (382 mg).

Provenance & Evidence