Sodium Hydroxide → HCID 59625183, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (3S,5R)-3-{[(2-tert-butyl-4-{[3-(methylsulfanyl)propyl]amino}pyrimidin-5-yl)carbonyl](2-methylpropyl)amino}-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}piperidine-1-carboxylate (1.12 g) in ethanol (10 ml) was added 4 M aqueous sodium hydroxide solution (10 ml), and the mixture was stirred at 80° C. for 12 hr. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, eluted with ethyl acetate-hexane (10:90-85:15) and concentrated under reduced pressure to give the object compound (119 mg).

Provenance & Evidence