HCID 59625608, compound → HCID 59625517, compound

Participants

Reaction Steps

To a solution of benzyl (3S,5R)-3-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}piperidine-1-carboxylate (550% mg) in acetic acid (14 ml) was added zinc-copper couple (200 mg) and the mixture was stirred at room temperature for 3 hr. Insoluble material was filtered off through celite, and the filtrate was concentrated under reduced pressure. Toluene was added to the residue, and the mixture was concentrated under reduced pressure. The obtained residue was diluted with saturated aqueous sodium hydrogen carbonate solution and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object compound (420 mg).

Provenance & Evidence