Styrene Oxide → HCID 59625181, compound

Participants

Reaction Steps

Benzyl (3R,5S)-3-amino-5-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]piperidine-1-carboxylate (100 mg) and 2-phenyloxirane (55 μl) were dissolved in acetonitrile (5 ml), and lithium perchlorate (55 mg) was added. The mixture was stirred at room temperature for 3 days and thereafter stirred at 80° C. for 7 hr. The reaction mixture was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, eluted with ethyl acetate-hexane-methanol (10:90:0-100:0:0-85:0:15) and concentrated under reduced pressure to give the object compound (53.2 mg).

Provenance & Evidence