Methyl iodide → HCID 59625403, compound

Participants

Reaction Steps

1-tert-Butyl 3-methyl (3R,5S)-5-{[(benzyloxy)carbonyl](2-methylpropyl)amino}piperidine-1,3-dicarboxylate (430 mg) and iodomethane (90 μl) were dissolved in DMF (5 ml), sodium hydride (50% contained, 70 mg) was added under ice-cooling, and the mixture was stirred at room temperature for 10 hr. The reaction mixture was diluted with saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object compound (500 mg).

Provenance & Evidence