Sodium Hydroxide → HCID 59625450, compound

Participants

Reaction Steps

Methyl 3-[(tert-butoxycarbonyl)amino]-N-({2-tert-butyl-4-[(furan-2-ylmethyl)amino]pyrimidin-5-yl}carbonyl)-N-(2-methylpropyl)-L-alaninate (200 mg) was dissolved in tetrahydrofuran-methanol (1:2, 18 ml), 2 M aqueous sodium hydroxide solution (0.95 ml) was added and the mixture was stirred for 4 hr. The reaction mixture was concentrated under reduced pressure, and diluted with saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and solvent was evaporated under reduced pressure to give the object compound (240 mg).

Provenance & Evidence