Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | HCID 58015512 | HCID 58015512 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ammonium Hydroxide | HCID 14923 | 1% |
| Product | HCID 58015478 | HCID 58015478 | 90.8% |
Reaction Steps
2-ethynyl-5-(2-methoxyethoxy)nicotinamide (2.04 g, 9 mmol) was dissolved in 1M dimethylamine (in methanol or ethanol) (46 ml, 93 mmol). The reaction was heated to 85° C. for 12 hrs. The reaction was concentrated and purified via MPLC eluting with 100% DCM to 90% DCM:10% MeOH:1% NH4OH to yield 3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (0.900 g, 44% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08198448B2 |
|---|
| Source dataset | uspto-grants-2012_06 |
|---|
| ORD ID | ord-99dcf9f3700343ceba44d1d01a402343 |
|---|
| Source note | uspto-grants-2012_06 |
|---|
