Triethylamine → HCID 59625362, compound

Participants

Reaction Steps

3-[(tert-Butoxycarbonyl)amino]-N-({2-tert-butyl-4-[(furan-2-ylmethyl)amino]pyrimidin-5-yl}carbonyl)-N-(2-methylpropyl)-L-alanine (147 mg), 1H-1,2,3-benzotriazol-1-ol ammoniate (130 mg) and triethylamine (160 μl) were dissolved in 1,2-dichloroethane-DMF (3:1, 15 ml), WSC.HCl (163 mg) was added and the mixture was stirred at room temperature for 21 hr. The reaction mixture was concentrated under reduced pressure, and diluted with saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and the fraction eluted with ethyl acetate-hexane (1:9) to ethyl acetate was concentrated under reduced pressure to give the object compound (90 mg).

Provenance & Evidence