Chloroform → HCID 68433470, compound

Participants

Reaction Steps

tert-Butyl (3S,5R)-3-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-{[4-(1-hydroxy-1-methylethyl)piperidin-1-yl]carbonyl}piperidine-1-carboxylate (120 mg) was dissolved in chloroform (3 ml), TFA (1 ml) was added and the mixture was stirred for 1 hr. The reaction mixture was concentrated, and the residue was dissolved in ethyl acetate, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was dissolved in methanol (2 ml), hydrochloric acid-methanol (2 ml) was added, and the solvent was evaporated under reduced pressure to give the object compound (66 mg).

Provenance & Evidence