Potassium Carbonate → HCID 59625488, compound

Participants

Reaction Steps

A solution of tert-butyl 4-[(trifluoroacetyl)amino]octahydroisoquinoline-2(1H)-carboxylate (1.75 g) and 20% aqueous potassium carbonate solution (10 ml) in methanol (25 ml) was stirred at 60° C. for 15 hr. The solvent was evaporated under reduced pressure, saturated brine (20 ml) was added to the residue, and the mixture was extracted with chloroform (30 ml×2). The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and the fraction eluted with ethyl acetate-methanol (1:0-9:1) was concentrated under reduced pressure to give the object compound (1.12 g) as an oil.

Provenance & Evidence