Isopropanol → HCID 67503623, compound

Participants

Reaction Conditions

Reaction Steps

A 330 mL pressure vessel was charged with 4,5-difluoro-2-(3-methylisoxazol-5-yl)pyridine (3.6695 g, 18.7 mmol), hydrazine (3.53 ml, 112 mmol), and IPA (93.5 ml, 18.7 mmol), sealed, then heated at 65° C. for 3 hours. The mixture was filtered; the solid was triturated with sat. aqueous NaHCO3 solution and washed with water (2×20 mL). 1-(4-fluoro-6-(3-methylisoxazol-5-yl)pyridin-3-yl)hydrazine (3.5668 g, 91.6% yield) was isolated as a white powder.

Provenance & Evidence