反应详情

Ethyl 2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)acrylate (3.50 g) was dissolved in methanol (42 mL), and to this solution was slowly added a 8 M aqueous potassium hydroxide solution (27 mL), which had been separately prepared. After stirring at room temperature for 3 hours, methanol was evaporated under reduced pressure, followed by careful addition of concentrated hydrochloric acid for neutralization. The resulting solid was collected by filtration, washed with water, and then dried by blowing air. The crude product was washed with diethyl ether and then dried under reduced pressure to obtain (2E)-2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)acrylic acid (2.47 g).

1. customhad been separately prepared
2. custommethanol was evaporated under reduced pressure
3. additionfollowed by careful addition of concentrated hydrochloric acid for neutralization
4. filtrationThe resulting solid was collected by filtration
5. washwashed with water
6. customdried
7. washThe crude product was washed with diethyl ether
8. customdried under reduced pressure