Hydrogen Bromide → HCID 67503082, compound

Participants

Reaction Conditions

Reaction Steps

A resealable pressure-resistant bottle was charged with ethyl 2-(3-methoxy-5-oxo-1,6-naphthyridin-6(5H)-yl)propanoate (0.83 g, 3.0 mmol) (Example 515) and conc. HBr (0.16 ml, 3.0 mmol). The vessel was sealed and the mixture was stirred at 130° C. for 20 hours. The reaction mixture was then concentrated to afford 2-(3-hydroxy-5-oxo-1,6-naphthyridin-6(5H)-yl)propanoic acid hydrobromide (0.95 g, 100% yield) as brown solid. This was carried through crude in the next step. Free base material MS m/z=235.0 [M+1]+. Calc'd for C11H11BrN2O4: 315.1.

Provenance & Evidence