Water → HCID 59570918, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-amino[1,3]thiazolo[5,4-b]pyridin-5-ol 2 hydrobromide (10 g) in DMF (20 mL) were added potassium carbonate (25.2 g) and 2-bromoethyl acetate (4 mL) at room temperature. It was stirred at 80° C. for 2 hours. To the reaction mixture were added saturated brine and water, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The obtained crude product was purified by silica gel column chromatography (hexane:ethyl acetate=1:2-1:3) to obtain 2-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]ethyl acetate (2.97 g) as a pale yellow solid.

Provenance & Evidence