反应详情

A mixture of [3-bromo-4-(cyclopropylsulfanyl)phenyl]acetic acid (13.5 g), concentrated sulfuric acid (0.135 mL), and methanol (40 mL) was stirred under heating and reflux for 4 hours. After leaving to be cooled at room temperature, the solvent was evaporated under reduced pressure, and then a 1 M aqueous sodium hydroxide solution (100 mL) was added to the reaction mixture, followed by extraction with ethyl acetate (100 mL×3). The organic layer was washed with saturated brine (100 mL) and dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure to obtain methyl [3-bromo-4-(cyclopropylsulfanyl)phenyl]acetate (13.8 g) as a colorless solid.

1. temperatureunder heating
2. temperaturereflux for 4 hours
3. customAfter leaving
4. customthe solvent was evaporated under reduced pressure
5. additiona 1 M aqueous sodium hydroxide solution (100 mL) was added to the reaction mixture
6. extractionfollowed by extraction with ethyl acetate (100 mL×3)
7. washThe organic layer was washed with saturated brine (100 mL)
8. dry with materialdried over anhydrous sodium sulfate
9. customthe solvent was then evaporated under reduced pressure